detection of carbapenemases emerging in acinetobacter baumannii clinical isolates by modified hodge test

Detection of Carbapenemases Emerging in Acinetobacter baumannii Clinical Isolates by Modified Hodge Test

Introduction: Acinetobacter baumannii, a known causative agent of nosocomial infections, is one of the highly antibiotic-resistant gram-negative bacilli. Carbapenem-resistant Acinetobacter isolates are increasingly reported worldwide. Carbapenems such as imipenem and meropenem are efficient antimicrobial agents commonly used for the treatment of infections caused by multi- resistant A. baumanni...

Detection of Carbapenemases Emerging in Acinetobacter baumannii Clinical Isolates by Modified Hodge Test

This bacterium has the propensity to acquire resistance rapidly to various classes of antimicrobial agents and so shows high rates of resistance to multiple antimicrobial agents [1, 2]. There is ongoing controversy as to whether carbapenem resistance results in an increased risk of mortality in patients infected with A. baumannii. The emergence of carbapenem-resistant A. baumannii is a signific...

Value of the modified Hodge test for detection of emerging carbapenemases in Enterobacteriaceae.

The modified Hodge test has an excellent sensitivity for detecting enterobacterial isolates producing Ambler class A (KPC) and class D (OXA-48) carbapenemases. Its sensitivity is low for NDM-1 producers (50%) but is increased to 85.7% by adding ZnSO(4) (100 μg/ml) in the culture medium. However, this test has a low specificity and is time-consuming.

Detection of kpc-type Carbapenemases in Clinical Isolates of Acinetobacter baumannii

Background: Multidrug-resistant Acinetobacter baumannii is associated with life threatening nosocomial infections and hospital outbreaks. The organism is resistant to most commonly used antibiotics including carbapenems. Aim and Objectives: To study carbapenemase production among multidrug-resistant clinical isolates of A. baumannii. Material and Methods: Fifty multidrug-resistant A. baumannii ...

Detection of Efflux Pump Using Ethidium Bromide-Agar Cartwheel Method in Acinetobacter baumannii Clinical Isolates

Introduction: In the past decade, multidrug-resistant Acinetobacter baumannii has become one of the most critical challenges in treating infected patients. The AdeABC efflux pump is the most important among the various resistance mechanisms. This pump can force various antibiotics and ethidium bromide out of the bacterial cell to the surrounding environment. Methods: In this study, nine A. baum...

Prevalence of Carbapenemases in Acinetobacter baumannii